Endocrine Abstracts

Introduction: The aim of this report is to present the uncommon clinical presentation of a patient with a pancreatic NET.Case report: A 55-year-old man with personal history of hypertension, dyslipidaemia, and depression. He was referred to the outpatient for high levels of calcium in repeated assessments during the last year. He referred polyuria and polydipsia. Not clinical history of bone fractures, abdominal pain, or another digestive symptoms. Initi...

Objective: To determine the degree of control of hypercholesterolemia in a specific lipid unit.Material and Methods: Retrospective study of patients followed in our unit over the past 16 years diagnosed with heterozygous familial hypercholesterolemia (HFH) or familial combined hyperlipidemia (FCH). Control criteria according to the following recommendations were compared: International Panel (2003), Nice (2008), NLA (2011), ESC / ESA 2011, Consensus ADA ...

Differentiated thyroid carcinoma is the most common endocrine malignant tumor. Papillary carcinoma frequency in our country is 80% of thyroid neoplasia. Papillary thyroid carcinoma usually metastasizes to cervical lymph. Metastases to distant organs are rare and most often affect the lungs, liver and bones. Despite of its anatomical proximity, metastasis parotid have not been described in the existing papillary carcinomas literature. We report a case of parotid gland metastasi...

Objective: Transition from pediatric to adult health care is a particularly vulnerable period for patients with inborn metabolic diseases.Our objective in this study was to evaluate the current transition of patients with phenylketonuria (PKU) in Malaga, Spain, by analysis of the metabolic control, medical care, patients satisfaction and phychosocial status.Material and methods: We evaluate all the patients transferred to our adult...

Introduction: LH and hCG act on the same receptor (LHCGR), have different half-lives and in vivo biopotency. It is not known whether they elicit the same cellular and molecular response. The aim of this study was to compare the kinetics of cAMP response to recombinant LH and hCG.Design: In COS-7 cells permanently expressing the human LHCGR (COS-7/LHCGR) we evaluated LH and hCG dose-response curves, by measuring total cAMP after 3 h of incubation. ...

Introduction: Metachronic metastasis of renal carcinoma to the thyroid gland, a rare entity occurring sometimes many years after nephrectomy, have been already reported by literature. Thyroidal synchronous metastasis, instead, are more uncommon. We herein report a patient with thyroidal metastasis and intrajugular thrombo embolic involvement as initial presentation of a misunderstood renal carcinoma.Case Report: A 83-years-old woman, with silent medical ...

We present a 27 year-old female patient suffering from multiple sclerosis (MS) since 3 years ago. She currently consults for menstrual disturbances. She has not any neurological secuelae of MS now and she is not on medical treatment. She is with amenorrhea since 10 months ago, but she had been oligomenorrhea just before for 24 months. She doesn’t have any symptoms suspicious for other hormonal impairment. Physical examination is normal.The laborator...

Statement of the problem: Thyroid nodules are one of the most common clinical problems encountered today. Detection of these nodules have been augmented with ultrasonography and fine needle aspiration biopsy (FNAB). Worldwide, the use of international standards of reporting such as the American Thyroid Association (ATA) Sonographic Pattern Risk Assessment and the Bethesda System for Reporting Thyroid Cytopathology have been proven to detect thyroid malignancies. However, ultra...

Lipocalin-2 (LCN2) is a glycoprotein synthetized by various cell types, including neutrophils, that acts as siderophores scavenger and play an important role in different chronic inflammatory processes. Metabolic Syndrome (MetS) and Adult Growth Hormone Deficiency (AGHD), both partial and total, are characterized by inflammatory features. The objectives of our cross-sectional study were: 1) to compare LCN2 levels in these clinical pictures; 2) to evaluate the relations between...

Background: Ghrelin and its endogenous antagonist liver-expressed antimicrobial peptide-2 (LEAP-2) are involved in GH secretion, both acting on GSH-r1α, and regulation of glucose and lipids metabolism. Metabolic impairments are often accompanied by an upregulation of LEAP-2 expression, with a usual concomitant reduction in ghrelin secretion. Adult growth hormone deficiency (aGHD), characterized by weight gain, increased fat mass and insulin resistance, represent a conditi...